1) everything would appear backwards to them, including people, locations, words, and any other images with which they were familiar.
2) they would be unable to absorb any chiral nutrients (nutrients with a "handedness"), since all sugars, amino acids, and proteins on Earth are "left-handed", and all creatures are designed to assimilate such left-handed nutrients. they would be able to drink water perfectly well, but they could not extract nutrients from any food.
so they would be very disoriented as they starved to death. not a fun way to go.